The principle of self-determination highlights the empowerment of people with neurodevelopmental disorders in most aspects of their life. It makes it possible for this population to express their values and wishes to have a better quality of life. Unfortunately, when it is necessary to talk about illness and healthcare, it becomes very difficult to meet the challenge of both issues and bad news, as well as clarify therapeutic opportunities and palliative care. Improving the awareness of people affected by neurodevelopmental disorders, their capacity of expression, comprehension and communication with professionals can provide them with the possibility of a choice as far as their health is concerned, in a quality-of-life perspective.