The majority of athletes have complete symptom resolution from 7 to 10 days following a concussion.1–4 In a small minority of individuals, the somatic, cognitive, and affective postconcussive symptoms become protracted and persist beyond the acute phase. This has been termed as postconcussive or postconcussion syndrome (PCS). In this chapter, we will review the debated definition and epidemiology, the proposed pathophysiological mechanism, specific factors that increase an athlete’s risk of developing PCS, and also the clinical management of common postconcussive symptoms that are persistent in PCS.