Saffron, the dried stigmas of the flower of Crocus sativus  Linnaeus, is the most expensive spice in the world, and therefore the target of fraudulent practices. Many different approaches have been developed for saffron fraud prevention, among which omic ones (genomics, proteomics, and metabolomics) show great potential. In recent years, many scientists have joined efforts and expertise to combat saffron fraud by enriching the armory of analytical methods in a complementary way within the frame of the COST Action FA1101 “ Saffron-OMICS.”  During the same period, other omic approaches were also reported on the same topic. This chapter covers the major recent 652analytical achievements, in the light of which existing regulatory measures for saffron fraud prevention are critically discussed.