ABSTRACT

Despite the effort devoted to understanding the molecular basis of embryo implantation, the process remains a biological enigma. Following fertilization, the resulting blastocyst must signal its presence to the mother, attach to the luminal epithelium of the endometrium, and embed itself into the decidualized stroma. Failure to do so results in no pregnancy. Events producing a negative impact on this process are intrinsically linked to the development of obstetric pathologies such as intrauterine growth restriction (IUGR) and preeclampsia, or the fetal origin of adult disease (FOAD) (1).