Hurler disease/mucopolysaccharidosis type IH (MPSIH)/α-L-iduronidase deficiency

Coarse features, mental retardation, corneal clouding, hepatosplenomegaly, short stature, dysostosis multiplex and cardiac complications; widespread lysosomal storage of mucopolysaccharide, and excretion of dermatan sulfate and heparin sulfate; and deficiency of α-L-iduronidase.