Naringi crenulata (Roxb) Nicolson (Family Rutaceae) is normally identified as Maha vilvam in Tamil Nadu and it is seen throughout India, particularly in the Southern Western Ghats. The objective of this review is to bring out a relationship between traditional uses and scientific studies through crucial evaluation of available fragmented literature on traditional uses, phytochemistry, and pharmacology of N. crenulata. It is powerfully believed that detailed information as presented in this chapter on the phytochemical and many biological activities of the plant extracts may provide detailed proof for the use of this plant in various medicines. Furthermore, this chapter highlighted the significance of N. crenulata and provided for future research studies.