ABSTRACT

The mechanisms of intestinal amino acid and peptide absorption are well characterized. Amino acids are transported across the intestinal brush border membrane (BBM) by several Na+ dependent active transport systems into the cytoplasma and leave the epithelial cell by facilitated diffusion through the basolateral membrane (BLM). 1–3 Thus, regulation of intestinal amino acid absorption may occur both at the BBM and BLM. Amino acid transport across the BBM might be modulated by changes in the driving force, the number of amino acid carriers, and the substrate affinity of the carriers. The same applies to the exit of amino acid across the BLM.