ABSTRACT
Introduction With advances in neonatal surgical techniques, survival has improved considerably for patients with congenital heart defects (CHDs). Although there has been a decline in gross neurologic insults in these children, many experience behavioral, emotional, cognitive, and motor impairments, suggesting widespread brain dysfunction. Given these outcomes, recent and ongoing research is focused on the impact of CHD on brain development, brain injury, and neurodevelopmental (ND) outcomes to better understand mechanisms of injury and identify potential therapeutic targets to improve outcome.
