The immune system relies on adequate dietary selenium (Se) intake and this nutrient exerts its biological effects mostly through its incorporation into selenoproteins (Huang et al. 2012). The selenoproteome contains 25 members in humans that exhibit a wide variety of functions. While many members of the selenoprotein family function as enzymes involved in redox reactions, some are likely not enzymes themselves, and functions are gradually becoming better understood for these non-enzymatic members (Reeves & Hoffmann 2009). Understanding how levels of dietary Se intake modulate immunity through different selenoproteins has been a challenge, but progress has been made in this field of study.