Selenium (Se) is an essential trace element for both animals and humans (Terry et al. 2000). Selenium deficiency has been linked to two kinds of diseases, which are endemic cardiomyopathy called Keshan disease and Kashin-Beck disease, a type of osteoarthritis. Therefore, Se supplements are necessary for those who are living in the areas with low Se. Selenium in Seenriched foods is more bioavailable than inorganic Se and are gradually adopted for use as Se supplements in the last ten years (Ge et al. 1983). The distribution of Se in different tissues and its physiological effects on animals with various forms of supplemental Se have been investigated in many studies (Whanger & Butler 1988, Mahan et al. 1999). However, there are few reports related to Se-enriched wheat and its effects on animals. Therefore, the aim of this study is to evaluate the effect of Se-enriched wheat on Se distribution of rats.