Selenium (Se) is a trace element with multiple biological functions. Low Se dietary intakes can result in health disorders and some diseases, such as reduced fertility and immune function, increased risk of cancers, and thyroid and cardiovascular diseases. Overt Se deficiency has caused endemic Keshan or Kaschin-Beck disease in areas of China with low Se diets (Tan et al. 2002). Unfortunately, the uneven distribution of Se over the Earth’s surface causes wide Se-deficient areas, leading to increased risk of the already mentioned health issues. Biofortification with Se is considered an effective approach for addressing the human Se deficiency status (Alfthan et al. 2015). Sweetpotato is an excellent candidate for the healthcentered strategy of producing functional foods with high levels of Se. The present research aimed to assess evaluate the effects of soil selenium content on agronomic characters, quality, and yield of sweet potato grown in soil enriched with different forms of Se.