ABSTRACT

Selenium (Se) is an essential trace element for mammals. Inadequate Se can aggravate the development of inflammatory bowel diseases (IBD). Selenium nanoparticles (SeNPs) are characterized by low toxicity and anti-inflammatory properties with functional modifications. In this study, we attached SeNPs with natural polysaccharides from Poria cocos polysaccharide (Pachyman, PYN), which has an anti-inflammatory effect. Herein, we explored PYN-SeNPs potential beneficial effects on IBD by the mice model subjected to acute colitis.