Typically, neonatal necrotizing enterocolitis (NEC) occurs in the premature infant, but about 10% of those affected with the condition are full-term. About half of these have coexisting risk factors. Specific congenital abnormalities, particularly congenital heart disease, are known to increase the likelihood of developing NEC, and mostly these are indicative of some form of perinatal stress. Nevertheless, the most common comorbidity in NEC remains prematurity and its sequelae.