Nanobiotechnology is a combination between nanotechnological and biological materials which is used for the development of novel biological agents at the nano scale (1–100 nm) that can be used in biomedical science. Nanoparticles are structures at the nano level (less than 100 nm) which possess specific biological activity resulting from their chemical and physical properties and maximum surface area to volume ratio. Therefore, nanoparticles can serve as potential candidates, especially in the field of medicine (nanomedicine). The metallic nanoparticles are the most promising candidate because they contain significant antimicrobial potential because of their wide surface area, which increases the scientific attention given to them by in the fight against multidrug-resistant microorganisms (Rai et al., 2009). The fact that the properties of nanoparticles have high constancy plays an important role in biomedical science applications. Therefore, there is a need to synthesize and optimize well-designed nanoparticles with fundamental properties like good stable size, shape, etc. (Wu and Gao, 2018; Bharti et al., 2019).