Design of Macromolecular Prodrug of Cisplatin Attached to Dextran through Coordinate Bond

doi:10.1201/9780429136405-17

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ABSTRACT

Cis-dichlorodiammineplatinum (II) (cisplatin, CDDP) has been widely used for clinical cancer therapy in spite of its severe renal toxicity [1] and low water-solubility.