Nano-sized drug deliveries have emerged since last few decades with the objective of controlled and targeted delivery of drugs. Lipidic nanoparticles (LNs) witnesses promising alternatives for various colloidal drug delivery systems viz., nanoemulsion, liposomes and polymeric nanoparticles. The biodegradable and biocompatible nature of LNs proves itself favorable among other polymeric nanoparticles. Furthermore, LNs ensure better therapeutics by modifying drug release kinetics, bio-distribution, and greater uptake in tissues. In spite of potential ability of LNs for drug delivery their manufacturing still, pose a challenge. The present chapter presents insight on LNs including basic component, manufacturing techniques, characterization parameters, and applications toward drug delivery.