Fucoidan is considered as “gold from the sea” and it has enormous application in the field of biological and biomedical applications. Fucoidan is a sulfated polysaccharide, and commonly observed in marine brown algae. Fucoidan has the ability to differentiate from stem cells to osteoblastic cells. Fucoidan can be converted into nanoparticles, hydrogels, nanofibers, microsphere and scaffolds for tissue engineering, drug delivery and wound dressing applications. Fucoidan structure and activity can vary depending on the brown seaweed source and geographical area.