ABSTRACT
During the past few years, interest in developing antisense technology and in exploiting it for therapeutic purposes has been intense. Although progress has been gratifyingly rapid, the technology remains in its infancy, and the questions that remain to be answered still outnumber the questions for which there are answers. Appropriately, considerable debate continues about this approach’s breadth of utility and the type of data required to “prove that a drug works through an antisense mechanism.”
