The first 1,000 days, from conception to two years of age, is a critical period of growth and development. Exposures to dietary, environmental, hormonal, and other stressors during this window have been associated with an increased risk of poor health outcomes, some of which are irreversible. The book addresses this crucial interval of early life across biological disciplines, linking concepts related to all biological fields to outcomes during the first 1,000 days (e.g. fetal growth and pregnancy outcomes) and beyond (e.g. gut microbiome and cardiovascular disease later in life). The strength of this book lies in its cross-disciplinary nature.

section I|2 pages


chapter 1|12 pages

The Importance of the First 1,000 Days

An Epidemiological Perspective
ByChristine M. McDonald, Andrew L. Thorne-Lyman
Size: 0.98 MB

section II|2 pages

What Is Normal Growth?

chapter 2|16 pages

World Health Organization Child Growth Standards

ByMercedes de Onis
Size: 0.91 MB

section III|2 pages

Nutritional Requirements in the Life Stages

chapter 3|18 pages

Nutrient Requirements and Recommendations during Pregnancy

ByMagali Leyvraz, Lynnette M. Neufeld
Size: 0.29 MB

chapter 4|22 pages

Nutrient Requirements during Lactation

ByVictoria Hall Moran
Size: 0.70 MB

chapter 5|12 pages

Nutrient Requirements of Infants and Young Children

ByMinghua Tang, Kathryn G. Dewey, Nancy F. Krebs
Size: 0.23 MB

section IV|2 pages

Endocrinology in the Regulation of Growth

chapter 6|16 pages

Hormonal Regulation during Lactation and Human Milk Production

ByWilliam R. Crowley
Size: 0.95 MB

chapter 7|16 pages

Thyroid Function and Growth

The Mechanisms of Iodine
ByJessica Farebrother, Fabian Rohner
Size: 1.29 MB

section V|2 pages

Adverse Pregnancy and Birth Outcomes (Pathophysiology and Consequences)

chapter 8|14 pages

Neural Tube Defects

Mechanisms of Folate
ByAnne M. Molloy
Size: 1.49 MB

chapter 9|8 pages

Cleft Lip and Palate

ByEman Allam, Ahmed Ghoneima, Katherine Kula
Size: 0.78 MB

chapter 10|10 pages

Obesity and Gestational Diabetes

ByMaria Farren, Michael J. Turner
Size: 0.19 MB

chapter 11|16 pages

Nutrition and Hypertensive Disorders of Pregnancy

ByAntonia W. Shand, Tim J. Green
Size: 3.67 MB

chapter 12|18 pages

Low Birth Weight and Small for Gestational Age in the Context of 1,000 Days

ByAmira M. Khan, Bianca Carducci, Zulfiqar A. Bhutta
Size: 0.83 MB

section VI|2 pages

Pathophysiology and Nutrition Requirements in Child Malnutrition

chapter 13|16 pages

Acute Malnutrition

ByAndré Briend
Size: 0.40 MB

chapter 14|14 pages

Management of Acute Malnutrition in Infants under 6 Months of Age

ByMarko Kerac, Marie McGrath
Size: 0.98 MB

chapter 15|16 pages

Chronic Malnutrition

BySaskia de Pee
Size: 0.42 MB

chapter 16|16 pages

Nutritional Regulation of the Growth Plate

ByJulian C. Lui
Size: 1.28 MB

section VII|2 pages

Body Composition

Size: 0.60 MB

chapter 18|18 pages

Body Composition Changes from Infancy to Young Childhood

ByDaniel J. Hoffman, Pamela L. Barrios
Size: 0.63 MB

section VIII|2 pages

The Gut Microbiome

chapter 19|14 pages

Early Life Gut Microbiome

ByChristopher J. Stewart, Stephen P. Cummings
Size: 0.80 MB
Size: 0.89 MB

section IX|2 pages

Effects of Early Life Exposures and Nutrition

chapter 21|12 pages

Effects of Early Diet on Childhood Allergy

ByMerryn Netting, Maria Makrides
Size: 0.26 MB

chapter 22|20 pages

Epigenetics, Nutrition, and Infant Health

ByPhilip T. James, Matt J. Silver, Andrew M. Prentice
Size: 2.91 MB

chapter 23|14 pages

Fetal Origins of Obesity, Cardiovascular Disease, and Type 2 Diabetes

ByHerculina Salome Kruger, Naomi S. Levitt
Size: 0.68 MB

section X|2 pages

Effective Interventions during the First 1,000 Days

chapter 24|18 pages

Effectiveness of Nutrition-Specific Interventions in Pregnancy and Early Childhood

ByRebecca Heidkamp, Adrienne Clermont, Robert E. Black
Size: 0.55 MB

chapter 25|20 pages

Nutrition-Sensitive Interventions for the First 1,000 Days

ByJessica Fanzo, Haley Swartz
Size: 1.60 MB

chapter 26|12 pages

Global Progress in the Scaling Up Nutrition (SUN) Movement

ByTom Arnold
Size: 1.60 MB

section XI|2 pages

Before and Beyond the 1,000 Days

chapter 27|16 pages

A Role for Preconception Nutrition

ByTaylor Marie Snyder, Homero Martinez, Sara Wuehler, Luz Maria De-Regil
Size: 0.27 MB

chapter 28|18 pages

Interpregnancy Intervals and Birth Spacing

ByAmanda Wendt, Usha Ramakrishnan
Size: 0.43 MB

chapter 29|14 pages

Adolescent Nutrition

A Critical Opportunity for Intervention
ByEmily Mates, Anne Bush
Size: 0.32 MB

section XII|2 pages

Discovery Research

chapter 30|12 pages

Metabolomics and Proteomics

Methodological Advances to Increase Our Knowledge of Biology during the First 1,000 Days
ByRichard D. Semba, Marta Gonzalez-Freire
Size: 0.82 MB