The factors affecting blood vitamin C levels are described in detail in this series. Many factors such as aging, smoking, infection, trauma, surgery, hemolysis, hormone administration, heavy metals, pregnancy, alcohol, ionizing radiation and several medicines have been found to cause a disturbance of ascorbic acid metabolism and to reduce blood vitamin C levels. Indeed, abnormalities of ascorbic acid metabolism, due to factors such as smoking, occur much more frequently than does dietary vitamin C deficiency today.It is now known that low blood vitamin C levels are associated with histaminemia (high blood histamine levels), and also that ascorbate-responsive histaminemia is common in apparently healthy people. High blood histamine levels are believed to cause small hemorrhages within the inner walls of the blood vessels and these may lead to the deposition of cholesterol, as an aberrant form of wound healing. Ascorbic acid not only reduces blood histamine levels, but also aids the conversion of cholesterol to bile acids in the liver. The clinical pathological and chemical changes observed in ascorbic acid deficiency are discussed in detail. Several diseases and disorders associated with low blood vitamin C levels are also described. Possible toxic effects resulting from the oxidation of ascorbic acid are noted, and reasons for the use of D-catechin or other chelating fiber to prevent or minimize the release of ascorbate-free radical are detailed. An excellent reference for physicians, nutritionists and other scientists

Part 3: Chemical Changes Associated with Vitamin C Deficiency 1. Histamine Metabolism 2. Proline and Lysine Metabolism 3.Carbohydrate Metabolism 4.Folic Acid Metabolism 5. Cholesterol Metabolism 6. Tyrosine and Phenylalanine Metabolism 7. Tryptophan Metabolism 8. Adrenal Corticoid Metabolism 9. Uric Acid Clearance Part 2: Clinical Conditions Associated with Disorders Of Ascorbic Acid Metabolism 10. Rheumatic Fever 11. Menorrhagia 12. Wound Dehiscence 13. Habitual Abortion 14. Abruption Placentae 15. Prematurity and Premature Rupture of the Foetal Membranes 16. Megaloblastic Anaemia of Infancy, Pregnancy, and Steatorrhea 17. Gastrointestinal Ulcers and Haemorrhage 18. Ocular Lesions 19. Cerebral Haemorrhage and Thrombosis 20. Coronary Thrombosis and Myocardial Infarction