ABSTRACT
Mathematical modelling is an important part of nuclear medicine. Therefore, several chapters of this book have been dedicated towards describing this topic. In these chapters, an emphasis has been put on describing the mathematical modelling of the radiation transport of photons and electrons, as well as on the transportation of radiopharmaceuticals between different organs and compartments. It also includes computer models of patient dosimetry. Two chapters of this book are devoted towards introducing the concept of biostatistics and radiobiology. These chapters are followed by chapters detailing dosimetry procedures commonly used in the context of diagnostic imaging, as well as patient-specific dosimetry for radiotherapy treatments.
For safety reasons, many of the methods used in nuclear medicine and molecular imaging are tightly regulated. Therefore, this volume also highlights the basic principles for radiation protection. It discusses the process of how guidelines and regulations aimed at minimizing radiation exposure are determined and implemented by international organisations. Finally, this book describes how different dosimetry methods may be utilized depending on the intended target, including whole-body or organ-specific imaging, as well as small-scale to cellular dosimetry.
This text will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine.
- The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine
- Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel
- Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history
Contents
Preface...............................................................................................................................vii
Editor..................................................................................................................................ix
Contributors.......................................................................................................................xi
Chapter 1 Introduction to Biostatistics..........................................................................1
Johan Gustafsson and Markus Nilsson
Chapter 2 Radiobiology....................................................................................................17
Lidia Strigari and Marta Cremonesi
Chapter 3 Diagnostic Dosimetry.............................................................................................33
Lennart Johansson† and Martin Andersson
Chapter 4 Time- activity Curves: Data, Models, Curve Fitting, and Model Selection..........................69
Gerhard Glatting
Chapter 5 Tracer Kinetic Modelling and Its Use in PET Quantification..............................................83
Mark Lubberink and Michel Koole
Chapter 6 Principles of Radiological Protection in Healthcare..........................................................101
Soren Mattsson
Chapter 7 Controversies in Nuclear Medicine Dosimetry..................................................................115
Michael G. Stabin
Chapter 8 Monte Carlo Simulation of Photon and Electron Transport in Matter..............................123
Jose M. Fernandez-Varea
Chapter 9 Patient Models for Dosimetry Applications..........................................................141
Michael G. Stabin
Chapter 10 Patient- specific Dosimetry Calculations.............................................................155
Manuel Bardies, Naomi Clayton, Gunjan Kayal, and Alex Vergara Gil
Chapter 11 Whole- body Dosimetry..................................................169
Jonathan Gear
Chapter 12 Personalized Dosimetry in Radioembolization........................................................................................183
Remco Bastiaannet and Hugo W.A.M. de Jong
Chapter 13 Thyroid Imaging and Dosimetry..........................................................................207
Michael Lassmann and Heribert Hanscheid
Chapter 14 Bone Marrow Dosimetry........................................................................................223
Cecilia Hindorf
Chapter 15 Cellular and Multicellular Dosimetry...................................................................235
Roger W. Howell
Chapter 16 Alpha- particle Dosimetry................................................................267
Stig Palm
Chapter 17 Staff Radiation Protection........................................................................275
Lena Jonsson
Chapter 18 IAEA Support to Nuclear Medicine...........................................................293
Gian Luca Poli
