Brain Slices in Basic and Clinical Research describes advancements in the field of brain function and dysfunction through use of central nervous system slice preparations. Topics are authored by leading scientists and include the following:

  • Mechanisms of synaptic plasticity as the basis of memory processes
  • Chaos and synaptic variability
  • Brain calcium currents
  • Glutamate receptors
  • Pathophysiology of excitotoxins
  • Cerebral hypoxia-ischemia
  • Neuronal injury
  • Free radicals
  • Optical methods of measuring brain metabolism
  • Voltammetry in brain slices
  • Calcium imaging
  • Patch-clamp recording and application of macromolecules through patch-clamp pipettes in brain slices
  • Intracellular double labeling of various neuronal populations
  • Use of brain slices in teaching neurophysiological methods
    Most of the topics are published in book format for the first time, and some of the techniques are more fully detailed than in any other book.
  • 1 Advances in Understanding the Mechanisms Underlying Synaptic Plasticity, 2 Chaotic Components of Synaptic Variability in Hippocampal Pathways, 3 Intrinsic Optical Properties of Brain Slices: Useful Indices of Electrophysiology and Metabolism, 4 Voltammetry in Brain Slices, 5 Imaging of Intracellular Calcium in Hippocampal Slices: Methods, Limitations, and Achievements, 6 Patch-Clamp Recording in Brain Slices, 7 Intracellular Application of Macromolecules Through Patch Pipettes in Brain Slices, 8 Intracellular Double Labeling of Substantia Nigra and Pedunculopontine Neurons in In Vitro Slice Preparation, 9 The Importance of Temperature Control When Investigating High-Threshold Calcium Currents in Mammalian Neurones, 10 A Neurochemical Approach to Elucidate Metabotropic vs. Ionotropic Glutamate Receptor Activities in Rat Hippocampal Slices, 11 Radiotracer Labeling of Brain Slices, 12 The Pharmacology of Excitotoxins and Energy Deprivation in Hippocampal Slices, 13 Delayed Neuronal Injury in the Hippocampal Slice, 14 Gene Expression as an Index of Pathophysiology Associated with Slice Preparation, 15 Studies on Anoxic Depolarization, 16 The Use of Brain Slices in the Study of Free Radical Actions, 17 Using the In Vitro Hippocampal Slice as a Model to Teach Methods in Neurophysiology, Index