ABSTRACT
Toxins and Biologically Active Compounds from Microalgae: Volume 2: Biological Effects and Risk Management is devoted to the effects toxic microalgae and their poisonous products exert on living systems and how they may affect human activities. The most advanced information regarding the molecular mechanisms of action of major groups of
Toxic microalgae and cyanobacteria. Harmful algae and their toxins: progress, paradoxes and paradigm shifts. Micro-algal and cyanobacterial producers of biotoxins. Detection and identification of toxic microalgae by the use of innovative molecular methodologies. Factors affecting algal toxicity. Microalgal toxins: chemistry and detection. Chemistry and detection of okadaic acid/dinophysistoxins, pectenotoxins and yessotoxins. Chemistry of brevetoxins. The chemistry of ciguatoxins: from the first records to current challenges of monitoring programs. Palytoxins: chemistry and detection. Chemistry and detection of domoic acid and isomers. Current knowledge of paralytic shellfish toxin biosynthesis, molecular detection and evolution. Current understanding and hypotheses on the biosynthesis of microalgal polyether toxins. Total synthesis of marine polycyclic ether natural products. Instrumental methods for determination of marine microalgal toxins. Biological assays for toxin detection: characteristics, potential and critical issues. Marine toxin detection methods in regulation - from validation to implementation.
