ABSTRACT
This title includes a number of Open Access chapters.This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including: host-pathogen interactionscausal relationships between genes and the environmentthe effects
The Link Between Epigenetics and Disease. The Epigenetics of Host-Pathogen Interactions. The Molecular Mechanisms of Epigenetic Regulation. Mutation Rate and DNA Methylation in the Human Genome. Causal Relationships in Gene-Environment Interactions. Lysine Acetylation in Transcriptional Programming and Metabolism. Histone Deacetylases in Epigenetic Regulation. Aberrant Epigenetic Silencing and Gene Expression. RNAi Silencing in Poly (ADP-Ribose) Research. MicroRNA Deregulation in Rhabdomyosarcoma and Neuroblastoma. Epigenetic Effects of Environmental Chemicals. DNA Sequence and Epigenome-Induced Pathologies. Analysis and Models for Understanding the Epigenetics-Pathology Connection. Next-Generation Sequencing Systems. DNA Sequencing and Epigenomics Research. Predictive Models of Gene Regulation. Issues in Understanding Epigenetics and Disease.
