Exploring the causes, mechanisms, and pathophysiology of cardiac remodeling, this reference offers detailed descriptions of the various components of the remodeling process, as well as new therapeutic interventions and recent and future prospects for the treatment of cardiac remodeling.

part I|1 pages

The Process of Remodeling

chapter 1|8 pages

Overview: Cardiac Remodeling and Its Relationship to the Development of Heart Failure

ByJay N. Cohn, Inder S. Anand

chapter 2|18 pages

Ventricular Remodeling in Pressure vs. Volume Overload

ByBlase A. Carabello

chapter 3|18 pages

Changes in the Interstitial Matrix During Myocardial Remodeling

ByAnne M. Deschamps, Francis G. Spinale

chapter 4|12 pages

Cardiac Myocyte Structural Remodeling

ByA. Martin Gerdes, Maurice S. Holder

chapter 5|16 pages

Myofilament Remodeling in the Failing Human Heart

ByPeter VanBuren, Martin M. LeWinter

chapter 6|18 pages

Alterations in Cardiac Myocyte Cytoskeleton

ByHenk L. Granzier

chapter 7|12 pages

Importance of Myocyte Loss and Regeneration During the Cardiac Remodeling Process

ByShaila Garg, Jagat Narula

chapter 8|18 pages

Remodeling from Compensated Hypertrophy to Heart Failure

Functional-Structural Correlations of Remodeling in the Human Heart
ByStefan Hein, Jutta Schaper

chapter 9|18 pages

Myocardial Remodeling: Physiological and Pathological

ByJeffrey S. Borer, Karl H. Schuleri

chapter 10|20 pages

Experimental Animal Models of Cardiac Remodeling

ByElaine J. Tanhehco, Hani N. Sabbah

chapter 11|30 pages

The Use of Genetically Modified Mice in the Investigation of Cardiac Remodeling

ByDaniel J. Lips, Rutger J. Hassink, Aart Brutel de la Riviere, Pieter A. Doevendans

part II|1 pages

Causes of Remodeling

chapter 12|26 pages

The Renin–Angiotensin–Aldosterone System in Cardiac Remodeling

ByBarry Greenberg

chapter 13|26 pages

Adrenergic Receptor Signaling and Cardiac Remodeling

ByGerald W. Dorn II, Lynne E. Wagoner

chapter 14|18 pages

The Role of Inflammatory Mediators in Cardiac Remodeling

ByGabor Szalai, Yasushi Sakata, Jana Burchfield, Shintaro Nemoto, Douglas L. Mann

chapter 15|26 pages

Oxidative Stress in Heart Failure: Impact on Cardiac Function and Ventricular Remodeling

ByLuciano C. Amado, Anastasios P. Saliaris, Joshua M. Hare

part III|1 pages

Clinical Aspects and Treatment of Cardiac Remodeling

chapter 16|17 pages

Natural History of Cardiac Remodeling

ByGary S. Francis, W. H. Wilson Tang

chapter 17|22 pages

Assessment of Ventricular Remodeling in Heart Failure

ByInder S. Anand

chapter 18|24 pages

Treatment of Remodeling: Inhibition of the Renin–Angiotensin–Aldosterone System

ByRichard D. Patten, Marvin A. Konstam

chapter 19|39 pages

Effects of Adrenergic Blockade on Cardiac Remodeling

ByHenry Ooi, Wilson S. Colucci

chapter 20|28 pages

The Effects of Cardiac Revascularization on the Remodeling Process

ByVictor A. Ferrari, Craig H. Scott, Martin St. John Sutton

chapter 21|24 pages

Reverse Remodeling After Heart Valve Replacement and Repair

ByLynne Hung, Shahbudin H. Rahimtoola

chapter 22|19 pages

Cardiac Remodeling After LVAD Placement

ByKenneth B. Margulies

chapter 24|22 pages

Other Surgical or Device-Based Approaches to Treating Cardiac Remodeling

ByV. Dor, M. Di Donato, M. Sabatier, F. Civaia

chapter 25|26 pages

Gene Transfer and Left Ventricular Remodeling

ByH. Kirk Hammond, David M. Roth

chapter 26|22 pages

Stem Cell/Myoblast Transplantation for Myocardial Regeneration

ByDonald Orlic, Marc S. Penn

chapter 27|6 pages

Future Directions in Cardiac Remodeling

ByBarry Greenberg