ABSTRACT

JAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis.

Features:

  • Details activation and microRNA-mediated regulation of JAK-STAT pathway
  • Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe
  • Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway.

An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics.

chapter 1|8 pages

Regulation of Cytokine Signaling by the JAK-STAT Pathway

ByNicolette Nadene Houreld

chapter 2|26 pages

The Structure-Function Bonhomie of JAK-STAT Molecules

ByRitobrata Goswami

chapter 3|14 pages

MicroRNA-Mediated Regulation of JAK-STAT Signaling in Non-Cancerous Human Diseases

ByChandra S. Boosani, Devendra K. Agrawal, Wanlin Jiang, Taylor Burke

chapter 4|20 pages

JAK-STAT Signaling in Asthma and Allergic Airway Inflammation

ByAmina Abdul Qayum, Tristan Hayes, Mark H. Kaplan

chapter 5|14 pages

Role of JAK-STAT Signaling in Atopic Dermatitis

ByRadomir M. Slominski, Matthew J. Turner

chapter 6|19 pages

JAK-STAT Signaling Pathway and Gliosis in Neuroinflammatory Diseases

ByHan-Chung Lee, Kai-Leng Tan, Pike-See Cheah, King-Hwa Ling

chapter 7|20 pages

JAK-STAT Signaling in Cardiovascular Disease

ByGeorge W. Booz, Raffaele Altara, Sean P. Didion

chapter 8|19 pages

Diabetes and Obesity: Abnormal JAK-STAT Signaling

ByMarcia J. Abbott

chapter 9|16 pages

JAK-STAT Signaling in Liver Fibrosis

ByMarwa K. Ibrahim, Noha G. Bader El Din

chapter 10|18 pages

Renal Disorders: Involvement of JAK-STAT Pathway

ByYuji Nozaki

chapter 11|47 pages

JAK-STAT Signaling in Hematologic Malignancies

ByThomas Pincez, Thai Hoa Tran

chapter 12|16 pages

Aberrant JAK-STAT Signaling in Hematopoietic Malignancies

ByParvis Sadjadian

chapter 13|16 pages

Immunodeficiency: Consequences of Mutations in JAK-STAT Signaling

ByDaniel Silberger, Duy Pham

chapter 14|12 pages

Targeting JAK-STAT Pathway for Various Inflammatory Diseases and Viral Infections

ByChristina Gavegnano, Raymond F. Schinazi