This book deals with the emerging concept that certain pathogenic bacteria and viruses, when infecting people with cancer, actively fight tumors, allowing their regression. Although such observations go back more than 100 years, use of specific bacterial strains, or viruses, usually genetically modified with known anticancer drugs, and their protein/peptide products, has gained ground in recent years, allowing significant cancer regression in clinical trials with stage III/IV cancer patients or even in pediatric brain tumor patients, often without any demonstration of toxicity. It is composed of 12 chapters written by pioneers in microbial, biotech, and cancer research and covers the emerging roles of various microorganisms and their products in cancer therapy. The book highlights the benefits of using conventional cancer treatments (such as chemo- and radiotherapies) with microbial-based therapies. Such combinatorial therapies have gained particular attention as a strategy to overcome drug resistance, and the readers of the book will discover their impact on fundamental research and promising results from clinical trials.

chapter Chapter 1|32 pages

Bifidobacterium as a Delivery System of Functional Genes for Cancer Therapy

ByChao Han, Yu-Qing Dai, Zi-Chun Hua, Geng-Feng Fu, Yan Yin, Bi Hu, Gen-Xing Xu

chapter Chapter 2|40 pages

Therapy with Oncolytic Clostridium novyi-NT: From Mice to Men

ByShibin Zhou

chapter Chapter 3|49 pages

Genetic Engineering of Clostridial Strains for Cancer Therapy

ByMaria Zygouropoulou, Aleksandra Kubiak, Adam V. Patterson, Nigel P. Minton

chapter Chapter 5|32 pages

Genetically Modified Salmonella as Cancer Therapeutics: Mechanisms, Advances, and Challenges

ByXiaoxin Zhang, Zi-Chun Hua

chapter Chapter 6|32 pages

Genetically Engineered Oncolytic Salmonella typhimurium

ByJin Hai Zheng, Jung-Joon Min

chapter Chapter 7|38 pages

Engineering Escherichia coli to Combat Cancer

ByCarlos Piñero-Lambea, David Ruano-Gallego, Gustavo Bodelón, Beatriz Álvarez, Luis Ángel Fernández

chapter Chapter 8|28 pages

Live P. aeruginosa as a Cancer Vaccine Vector

ByY. Wang, B. Polack, B. Toussaint

chapter Chapter 9|20 pages

The Anticancer Potential of the Bacterial Protein Azurin and Its Derived Peptide p28

ByAna Rita Garizo, Nuno Bernardes, Ananda M. Chakrabarty, Arsénio M. Fialho

chapter Chapter 10|28 pages

Prospective Therapeutic Applications of Bacteriocins as Anticancer Agents

ByLígia F. Coelho, Nuno Bernardes, Arsénio M. Fialho

chapter Chapter 11|43 pages

Bacteriocins as Anticancer Peptides: A Biophysical Approach

ByFilipa D. Oliveira, Miguel A.R.B. Castanho, Diana Gaspar

chapter Chapter 12|26 pages

Where Cancer and Bacteria Meet

ByAlexandra Merlos, Ricardo Perez-Tomás, José López-López, Miguel Viñas