Babies of women with diabetes are nearly five times more likely to be stillborn and almost three times more likely to die in the first three months. The incidence of gestational diabetes mellitus in the U.S. is high—between 3 and 7 percent—and rising. The condition is often complicated by other risk factors such as obesity and heart disease.

The Textbook of Diabetes and Pregnancy presents a comprehensive review of the science, clinical management, and medical implications of gestational diabetes mellitus, a condition with serious consequences that is on the increase in all developed societies. This new edition supports the latest initiatives and strategies of the International Federation of Gynecology and Obstetrics (FIGO) and adds chapters on noncommunicable diseases, obesity, bariatric surgery, and epidemiology outside Western cultures.

Written by a cadre of experts, the book provides a comprehensive, authoritative, and international view of gestational diabetes mellitus and will be invaluable to maternal-fetal medicine specialists, diabetologists, neonatologists, and a growing number of gynecologists and general physicians concerned with the management of noncommunicable diseases in pregnancy.

chapter 1|10 pages

Introduction: Merging the legacies and hypotheses— Maternal medicine meets fetal medicine

ByMoshe Hod, Kypros Nicolaides, Hamutal Meiri, Nicky Lieberman

chapter 2|6 pages

History of diabetic pregnancy

ByDavid R. Hadden

chapter 3|11 pages

Metabolism in normal pregnancy

ByEmilio Herrera, Henar Ortega-Senovilla

chapter 4|6 pages

Intermediary metabolism in pregnancies complicated by gestational diabetes

ByBartolomé Bonet, María Bonet-Alavés, Isabel Sánchez-Vera

chapter 5|15 pages

Nutrient delivery and metabolism in the fetus

ByWilliam W. Hay, Paul J. Rozance, Stephanie R. Wesolowski, Laura D. Brown

chapter 6|8 pages

Pathogenesis of gestational diabetes mellitus

ByYariv Yogev

chapter 7|12 pages

Autoimmunity in gestational diabetes mellitus

ByAlberto de Leiva, Dídac Mauricio, Rosa Corcoy

chapter 8|9 pages

Epidemiology of gestational diabetes mellitus

ByYariv Yogev, Avi Ben Haroush, Moshe Hod, Jeremy Oats

chapter 9|6 pages

Genetics of diabetic pregnancy

ByKomal Bajaj, Susan J. Gross

chapter 10|7 pages

Animal models in diabetes and pregnancy research

ByCatherine Yzydorczyk, Delphine Mitanchez, Umberto Simeoni

chapter 11|6 pages

Pathologic abnormalities of placental structure and function in diabetes

ByRhonda Bentley-Lewis, Maria Rosaria Raspollini, Drucilla Roberts

chapter 12|3 pages

The great obstetric syndromes: The roots of disease

ByRinat Gabbay-Benziv, Ahmet A. Baschat

chapter 13|10 pages

Placental origins of diabesity and the origin of preeclampsia

ByGernot Desoye, Berthold Huppertz

chapter 14|9 pages

Diagnosis of gestational diabetes mellitus

ByDonald R. Coustan, Boyd E. Metzger

chapter 15|12 pages

Cost-effectiveness of screening and management programs for gestational diabetes mellitus

ByLouise K. Weile, James G. Kahn, Elliot Marseille, Nicolai Lohse

chapter 16|5 pages

Changing health policy: From study to national policy

ByOfra Kalter-Leibovici, Nicky Lieberman, Ronni Gamzu, Moshe Hod

chapter 17|2 pages

Ideal weight gain in diabetic pregnancy

ByGerard H.A. Visser, Harold W. de Valk

chapter 18|9 pages

Medical nutritional therapy for gestational diabetes mellitus

ByLois jovanovic

chapter 19|10 pages

Pharmacologic treatment of gestational diabetes mellitus: When to start and what agent to use

ByCeleste P. Durnwald, Mark B. Landon

chapter 20|12 pages

Gestational diabetes mellitus: The consequences of not treating

ByOded Langer

chapter 21|10 pages

Gestational diabetes mellitus in multiple pregnancies

ByMatteo Andrea Bonomo, Angela Napoli

chapter 23|13 pages

Insulin therapy in pregnancy

ByLois Jovanovic, John L. Kitzmiller

chapter 24|11 pages

Use of oral hypoglycemic agents in pregnancy

ByOded Langer

chapter 25|8 pages

The drug dilemma of oral antidiabetic agents in pregnancy: Metformin

ByYoel Toledano, Moshe Zloczower, Nicky Lieberman

chapter 27|8 pages

Links between maternal health and noncommunicable diseases

ByAnil Kapur

chapter 28|8 pages

Diabetic pregnancy in the developing world

ByEran Hadar, Eran Ashwal, Moshe Hod

chapter 29|4 pages

Managing diabetic pregnancy in China

ByHuixia Yang, Weiwei Zhu, Rina Su

chapter 30|7 pages

Gestational diabetes mellitus, obesity, and pregnancy outcomes

ByHarold David McIntyre, Marloes Dekker-Nitert, Helen Lorraine Graham Barrett, Leonie Kaye Callaway

chapter 32|7 pages

Pharmacological treatment for the obese gestational diabetes mellitus patient

ByFiona C. Denison, Rebecca M. Reynolds

chapter 34|14 pages

Role of bariatric surgery in obese women planning pregnancy

ByRon Charach, Eyal Sheiner

chapter 35|12 pages

Fetal lung maturity

ByGian Carlo Di Renzo, Giulia Babucci, Graziano Clerici

chapter 36|6 pages

Monitoring during the later stage of pregnancy and during labor: Glycemic considerations

ByHarold W. de Valk, Gerard H.A. Visser

chapter 37|7 pages

Timing and mode of delivery

BySalvatore Alberico, Gianpaolo Maso

chapter 38|3 pages

Management of the macrosomic fetus

ByFederico Mecacci, Marianna Pina Rambaldi, Giorgio Mello

chapter 40|8 pages

diabetic embryopathy in the preimplantation embryo

ByAsher Ornoy, Noa Bischitz

chapter 41|22 pages

Postimplantation diabetic embryopathy

ByUlf J. Eriksson, Parri Wentzel

chapter 43|6 pages

Continuous glucose monitoring in pregnancy

ByMarlon Pragnell, Aaron Kowalski

chapter 44|5 pages

Insulin infusion pumps in pregnancy

ByIlana Jaye Halperin, Denice S. Feig

chapter 45|8 pages

Closed-loop insulin delivery in type 1 diabetes pregnancy

ByZoe A. Stewart, Helen R. Murphy

chapter 46|10 pages

Noninvasive glucose monitoring

ByItai Ben-David, Pierre Singer

chapter 47|12 pages

Reproduction and its impact on health and disease

BySara Ornaghi, Michael J. Paidas

chapter 48|5 pages

Diabetes, pregnancy, and the developmental origins of health and disease

ByGerard H.A. Visser, Mark A. Hanson

chapter 51|7 pages

Can fetal macrosomia be predicted and prevented?

ByMaria Farren, Michael Turner

chapter 52|9 pages

Hypoglycemia in diabetic pregnancy

ByGraziano Di Cianni, Cristina Lencioni, Emilia Lacaria, Laura Russo

chapter 53|12 pages

Hypertensive disorders and diabetic pregnancy

ByJacob Bar, Moshe Hod, Michal Kovo

chapter 54|13 pages

Diabetic retinopathy

ByNir Melamed, Moshe Hod

chapter 55|7 pages

Diabetic nephropathy

ByElisabeth R. Mathiesen, Lene Ringholm, Peter Damm

chapter 56|6 pages

Diabetic ketoacidosis

ByAnnunziata Lapolla, Maria Grazia Dalfrà

chapter 57|10 pages

Thyroid disease in pregnancy

ByYoel Toledano, Gabriella Solomon

chapter 58|13 pages

Quality of care for the woman with diabetes at pregnancy

ByAlberto de Leiva, Rosa Corcoy, Alejandra de Leiva-Pérez, Eulàlia Brugués

chapter 59|10 pages

Early Pregnancyy loss and perinatal mortality

ByKinneret Tenenbaum-Gavish, Anat Shmuely, Moshe Hod

chapter 60|7 pages

Short-term implications of gestational diabetes mellitus: The neonate

ByDelphine Mitanchez, Catherine Yzydorczyk, Umberto Simeoni

chapter 61|5 pages

Long-term outcomes after gestational diabetes mellitus exposure in the offspring

ByDelphine Mitanchez, Catherine Yzydorczyk, Umberto Simeoni

chapter 62|5 pages

Metabolomics and diabetic pregnancy

ByAngelica Dessì, Roberta Carboni, Vassilios Fanos

chapter 63|6 pages

Fetal growth restriction: Evidence-based clinical management

ByEduard Gratacós, Francesc Figueras