ABSTRACT
Cancer remains one of the most challenging issues in modern medicine, being responsible for a high number of deaths every year. Recent important developments in cancer diagnosis and therapy based on the versatility of nanosystems have made it possible to incorporate multifunctional synergistic actions into a single delivery system.
This book compiles the research on the use of functional lipid nanosystems that combine different strategies in one single nanosystem to enhance overall cancer treatment. Besides providing an overview of the current functional nanosystem strategies, it also offers researchers essential theoretical background on cancer, the physiological barriers to its treatment, aspects related to the design and optimization of nanocarriers for cancer treatment, and clinical developments, including promises, safety issues, and the expected future. The editors bring together a group of scientists from all over the world to discuss the most relevant issues and to provide updates on functional lipid nanosystems and cancer.
Part 1: General Aspects of Cancer Pathology and Treament Options 1. Physiological Barriers in Cancer: A Challenge to Be Overcome 2. Cancer Chemotherapy, Bioactive Compounds, and Immunotherapy Part 2: General Aspects of Functional Lipid Nanotherapy 3. General Aspects of a Multifunctional Nanosystem Part 3: Multifunctional Lipid Nanosystems for Cancer: Research Highlights 4. Co-delivery of Anticancer Therapeutics via Lipid-Based Nanoscale Delivery Systems 5. Lipid-Based Nanocarriers for Co-delivery of Anticancer Drugs and Natural Compounds 6. Co-delivery of Anticancer Drug and Adjuvant Agents 7. Hybrid Nanosystems Composed by Lipid and Polymer Materials 8. Lipid Nanosystems: Targeted Nano-delivery of Therapeutic Agents in Treatment of Cancer 9. Monoclonal Antibody Ligands for Liposomes Functionalization: Immunoliposomes Formulation and Clinical Status 10. Active Targeting for Tumor Microenvironment: Integrin Binding Peptides 11. Targeting Liposomes to Metastatic Tumors with Antibodies Specific for VCAM-1 12. Active Targeting: Mitochondria-Targeting Signal Peptides 13. Recent Developments of Light: Triggered Liposome Nanosystems for Cancer Treatments 14. Ultrasound-Responsive Nanosystems 15. Lipid-Based Nanosystems for Gene and Drug Co-delivery in Cancer Therapy 16. The Therapeutical Window of Light: Modulating Receptor Proteins and Metabolic Pathways with Light and Its Importance for Disease Control 17. Magnetic Lipid-Based Nanosystems for Combined Therapy of Cancer
