ABSTRACT

Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling.

Key Features

  • Discusses the signaling pathways that contribute to successful
    spermatogenesis
  • Covers comprehensive information about Spermatogenesis at
    one place
  • Explores the vital aspects of male fertility and infertility
  • Explains the epigenetic regulation of germ cell development
    and fertility
  • Highlights the translational opportunities in molecular signaling
    in testis

chapter 1|9 pages

Primordial germ cells: Origin, migration and testicular development

BySaumya Sarkar, Rajender Singh

chapter 2|6 pages

DNA methylation, imprinting and gene regulation in germ cells

BySaumya Sarkar, Rajender Singh

chapter 3|13 pages

Testicular stem cells, spermatogenesis and infertility

ByDeepa Bhartiya, Sandhya Anand, Hiren Patel, Ankita Kaushik, Sreepoorna Pramodh

chapter 4|10 pages

Testicular germ cell apoptosis and spermatogenesis

ByBineta Singh, Gopal Gupta

chapter 5|9 pages

Hormonal regulation of spermatogenesis

ByPallav Sengupta, Mohamed Arafa, Haitham Elbardisi

chapter 6|11 pages

GH–IGF1 axis in spermatogenesis and male fertility

ByAntonio Mancini, Carmine Bruno, Andrea Palladino, Edoardo Vergani, Elena Giacchi

chapter 7|14 pages

Retinoic acid signaling in spermatogenesis and male (in)fertility

ByDario Santos, Rita Payan-Carreira

chapter 8|8 pages

Testosterone signaling in spermatogenesis, male fertility and infertility

ByArijit Chakraborty, Vertika Singh, Kiran Singh, Rajender Singh

chapter 9|10 pages

Wnt signaling in spermatogenesis and male infertility

ByVertika Singh, Meghali Joshi, Kiran Singh, Rajender Singh

chapter 10|10 pages

MAPK signaling in spermatogenesis and male infertility

ByArchana Devi, Bhavana Kushwaha, Gopal Gupta

chapter 11|11 pages

TGF-β signaling in testicular development, spermatogenesis, and infertility

ByPoonam Mehta, Meghali Joshi, Rajender Singh

chapter 12|16 pages

Notch signaling in spermatogenesis and male (in)fertility

ByMahitha Sahadevan, Pradeep G. Kumar

chapter 13|4 pages

Hedgehog signaling in spermatogenesis and male fertility

BySandeep Kumar Bansal, Meghali Joshi, Rajender Singh

chapter 14|7 pages

mTOR signaling in spermatogenesis and male infertility

ByArchana Devi, Gopal Gupta

chapter 15|13 pages

JAK-STAT pathway: Testicular development, spermatogenesis and fertility

ByPoonam Mehta, Rajender Singh

chapter 16|8 pages

PI3K signaling in spermatogenesis and male infertility

ByArchana Devi, Gopal Gupta

chapter 17|7 pages

Spermatogenesis, heat stress and male infertility

ByJohn J. Parrish