Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:key interplay between transporters and enzymes

chapter 1|30 pages

Introducing Pharmacokinetic and Pharmacodynamic Concepts

ByMalcolm Rowland

chapter 2|22 pages

In Vitro Enzyme Kinetics Applied to Drug-Metabolizing Enzymes

ByKenneth R. Korzekwa

chapter Chapter 3|33 pages

Human Cytochromes P450 and Their Role in Metabolism-Based Drug-Drug Interactions

ByStephen E. Clarke, Barry C. Jones

chapter Chapter 4|47 pages


ByRory P. Remmel, Jin Zhou, Upendra A. Argikar

chapter 5|70 pages

Drug-Drug Interactions Involving the Membrane Transport Process

ByHiroyuki Kusuhara, Yuichi Sugiyama

chapter 6|26 pages

In Vitro Models for Studying Induction of Cytochrome P450 Enzymes

ByJose M. Silva, Deborah A. Nicoll-Griffith

chapter |76 pages

The Role of P-Glycoprotein in Drug Disposition: Significance to Drug Development

ByMatthew D. Troutman, Gang Luo, Beverly M. Knight, Dhiren R. Thakker, Liang-Shang Gan

chapter 9|36 pages

Cytochrome P450 Protein Modeling and Ligand Docking

ByK. Anton Feenstra, Chris de Graaf, Nico P. E. Vermeulen

chapter 10|44 pages

Role of the Gut Mucosa in Metabolically Based Drug-Drug Interactions

ByKenneth E. Thummel, Danny D. Shen, Nina Isoherranen

chapter 11|30 pages

Mechanism-Based Inhibition of Human Cytochromes P450: In Vitro Kinetics and In Vitro–In Vivo Correlations

ByXin Zhang, David R. Jones, Stephen D. Hall

chapter 13|14 pages

Metabolism and Transport Drug Interaction Database: A Web-Based Research and Analysis Tool

ByHouda Hachad, Isabelle Ragueneau-Majlessi, René H. Levy

chapter Chapter 15|22 pages

Drug-Drug Interactions: Clinical Perspective

ByDavid J. Greenblatt, Lisa L. von Moltke

chapter Chapter 16|21 pages

An Integrated Approach to Assessing Drug-Drug Interactions: A Regulatory Perspective

ByShiew-Mei Huang, Lawrence J. Lesko, Robert Temple

chapter Chapter 17|22 pages

Drug-Drug Interactions: Toxicological Perspectives

BySidney D. Nelson

chapter Chapter 18|11 pages

Drug-Drug Interactions: Marketing Perspectives

ByKevin J. Petty, Jose M. Vega