ABSTRACT

This book provides the first comprehensive review of research that addresses the immunomodulation of gastrointestinal motility. Results from this new field of research are important for understanding motility disturbances and symptom-generation in a variety of clinical gastroenterological problems, including ulcerative colitis, Crohn's disease, enteric infections, and food allergies. The book provides overviews on current perspectives regarding the nature of inflammatory processes, inflammatory mediators, and other immune factors. It also describes a variety of experimental approaches that have been used to study the interactions between immune cells and smooth muscle or enteric nerves. The approaches include in vivo, as well as in vitro studies. Researchers involved in the general field of immunophysiology, as well as the more specific fields of gastrointestinal motility and inflammatory bowel diseases will find this book to be invaluable in their research.

chapter |9 pages

Acute and Chronic Inflammation

ByJack Gauldie

chapter |14 pages

Healing and Repair

ByRobert H. Riddell

chapter |9 pages

Cholesterol Feeding and Gallbladder Muscle Contractility

ByNorman W. Weisbrodt, Young Fang Li, Frank G. Moody, Diane Haley-Russell, Stuart I. Myers

chapter |10 pages

Inflammation Alters Smooth Muscle Function in the Gut: Studies on the Nematode-Infected Rat

ByS.M. Collins, D.L. Vermillion, J.D. Huizinga, M.J. Muller

chapter |10 pages

In-vivo Colonic Motility and Transit in Ulcerative Colitis

ByS. Narasimha Reddy, Gabriele Bazzocchi, Simon Chan, Kathy Akashi, Javier Villanueva-Meyer, George Yanni, Ismael Mena, William J. Snape

chapter |17 pages

Effect of Mucosal Inflammation on Colonic Smooth Muscle Contraction

ByYining Xie, William T. Gerthoffer, S. Narasimha Reddy, Viktor E. Eysselein, Fabio Cominelli, William J. Snape

chapter |11 pages

In Vivo Motor Response to Gut Inflammation

BySushil K. Sarna, Mary F. Otterson, Verne E. Cowles, Ashwani K. Sethi, Gordon L. Telford

chapter |10 pages

Smooth Muscle Function in Inflammatory Bowel Disease

ByJan D. Huizinga, Dianne L. Vermillion, Carla Cuthbert, Stephen M. Collins

chapter |12 pages

Smooth Muscle Growth in the Inflamed Intestine of the Rat

ByM.G. Blennerhassett, S.M. Collins

chapter |12 pages

Gut Neuropeptides and the Pathophysiology of Inflammatory Bowel Disease

ByTimothy R. Koch, Amnon Sonnenberg, J. Aidan Carney

chapter |11 pages

Visceral Afferent Innervation and Inflammation

ByHelen E. Raybould, Emeran Mayer

chapter |17 pages

Intestinal Inflammation in the Parasitized Host

ByGilbert A. Castro

chapter |10 pages

Mast Cell and Muscle Interactions in Animals and Man

ByDianne L Vermillion, Stephen M Collins, Jan D Huizinga

chapter |9 pages

The Effect of Activated Inflammatory Cells on Colonic Smooth Muscle Contraction

ByLin Chang, Martha Hierro, Louise E. LeDuc, Fergus Shanahan, Fabio Cominelli, William J. Snape

chapter |14 pages

Lymphocyte Interactions with Smooth Muscle Cells and Nerves

ByK. Geboes, P. Rutgeerts, V. Desmet

chapter |9 pages

Inflammatory Mediators and Gastrointestinal Motility

ByJohn L. Wallace, Nancy I.A. Byles, R. Brent Scott

chapter |13 pages

Putative Mediators in Inflammatory Bowel Disease: Substance P and Calcitonin Gene-Related Peptide.

ByViktor E. Eysselein, Catia Sternini, Fabio Cominelli, Cynthia C. Nast

chapter |9 pages

The Role of Granulocyte-Derived Oxidants in Intestinal Mucosal Injury

ByTamaki Yamada, Matthew B. Grisham

chapter |10 pages

Role of Interleukin-1 in Experimental Colitis

ByFabio Cominelli

chapter |12 pages

Intestinal Muscle Effects of Clostridium Difficile Toxins

ByRichard J. Gilbert

chapter |11 pages

Ischemia-Reperfusion: A Model of Acute Intestinal Inflammation

ByBarbara J. Zimmerman, Paul Kubes, D. Neil Granger

chapter |11 pages

Intestinal Effects of Bacterial Chemotactic Peptides: Induction of Inflammation, Release of Eicosanoids.

ByLouise E. LeDuc, Cynthia C. Nast, Fergus Shanahan, Alda Vidrich

chapter |10 pages

Idiopathic Colitis and Colon Cancer in the Cotton-Top Tamarin

ByJ. D. Wood, O. C. Peck

chapter |12 pages

Modulation of Gallbladder Contraction by the Oxidant Monochloramine

ByT.S. Gaginella, C. Moummi, G.W. Gullikson