ABSTRACT

Lymphatic Transport of Drugs provides a thorough review of the determinants that affect the uptake and delivery of drugs and xenobiotics to the lymphatics. Factors affecting the transport and delivery of lipophilic drugs through the lymph after oral administration, lymphatic transport of polar drugs and macromolecules after gastrointestinal dosing, transport of drugs into the lymph after parenteral administration, and particulate drug delivery systems are among the topics examined in this volume. Lymphatic Transport of Drugs is primarily intended for pharmaceutical scientists who are attempting to alter the delivery of current therapeutic agents through formulation of prodrugs, as well as for researchers designing new drugs for lymph delivery.

chapter 1|30 pages

Anatomy and Physiology of the Lymphatics

ByCaitriona O’Driscoll

chapter 2|26 pages

Intestinal Processing of Dietary Lipids

ByCharles M. Mansbach

chapter 3|49 pages

Methodologies for Assessing Intestinal Lymphatic Transport

ByThomas J. Raub, Scott L. Douglas, George W. Melchior, William N. Charman, Walter Morozowich

chapter 5|30 pages

Lipophilic Prodrugs and the Promotion of Intestinal Lymphatic Drug Transport

ByValentino J. Stella, Nancy L. Pochopin

chapter 7|21 pages

Lymphatic Transport of Polar Drugs After Gastrointestinal Administration

ByHiroshi Yoshikawa, Shozo Muranishi

chapter 8|23 pages

Lymphatic Transport After Parenteral Drug Administration

ByYoshinobu Takakura, Mitsuru Hashida, Hitoshi Sezaki

chapter 9|37 pages

Particulates and Lymphatic Drug Delivery

ByDerek T. O’Hagan, Nicola M. Christy, Stanley S. Davis