Apoptosis is an essential process in embryonic development and tissue homeostasis, particularly in the prevention of disease. Written from a genetic viewpoint, Genetics of Apoptosis first describes the molecular and cell biology of apoptosis, then examines the process in more detail in several model systems. This volume brings together contributions from internationally renowned authors, and will be a valuable reference to all researchers studying apoptosis.

chapter 1|18 pages

Death receptors in apoptosis

1. Introduction

chapter 1|3 pages

-Death receptors in apoptosis 19

chapter 22|5 pages

Genetics of Apoptosis

chapter 1|4 pages

-Death receptors in apoptosis 27

7.3 Targeting death receptors for treatment of cancers

chapter 5|2 pages

Specialists or generalists?

chapter 4|10 pages

. Functional domains in apoptosis proteins

1. Int roduction

chapter 5|7 pages

Other important domains

5.1 The Bcl-2 motif family

chapter 110|5 pages

Genetics of Apoptosis

chapter 6|9 pages

. Mitochondria in apoptosis induction

1. Int roduction

chapter 6|6 pages

-Mitochondria in apoptosis induction 129

chapter 7|2 pages

Regulators and applications of yeast apoptosis

1. Introduction

chapter |1 pages

Ack nowledgments

chapter 9|3 pages

. Programmed cell death in

1. Int roduction

chapter 158|17 pages

Genetics of Apoptosis

chapter 14|2 pages

Conclusion Acknowledgments

germ-cell apoptosis could also be explained by developmental checkpoints that lead to the demise of naturally occurring compromised germ cells. Similarly, sim­ ple alterations in the metabolism of germ cells could also lead to programmed cell death. Indeed, this hypothesis is supported by the fact that a large number of genetic loci lead to excessive germ-cell apoptosis (S. Milstein, Anton Gartner,

chapter 10|4 pages

Apoptosis in Drosoph ila

1. Int roduction

chapter 10|8 pages

-Apoptosis in Drosophila 181

chapter 11|14 pages

Cell-culture systems In apoptosis

1. Introduction: advantages of cell culture to investigate apoptosis

chapter 12|8 pages

. Caspase-independent cell death

1. Introduction

chapter 12|14 pages

-Caspase-independent cell death 211